职称:副教授

 

导师类型:博士研究生导师

 

个人简介:

王广成,博士、副教授、博士研究生导师、中组部“西部之光”访问学者、贵州省“千人创新创业”人才。2008年本科毕业于安徽中医学院药学专业,获理学学士学位;2011年硕士毕业于四川大学华西药学院药物化学专业获理学硕士学位;2014年博士毕业于四川大学生物治疗国家重点实验室药物化学专业获理学博士学位。目前承担《天然药物化学》、《波谱解析》、《药物分离纯化技术》、《高等天然药物化学》等课程的教学工作。

已主持国家自然科学基金、贵州省 “千人创新创业” 项目、贵州省科技厅重点项目等10余个科研项目。目前以第一作者/通讯作者身份Food ChemistryCritical Reviews in Food Science and NutritionEuropean Journal of Medicinal ChemistryBioorganic Chemistry等期刊发表SCI论文42篇(总影响因子149.2,其中18JCR一区论文。此外,在2017年发表于European Journal of Medicinal Chemistry的论文入选ESI高被引论文

以第一发明人身份申请发明专利10余项,其中9项获得授权。担任50余个国内外知名学术期刊审稿人,并被European Journal of Medicinal ChemistryBioorganic ChemistryBioorganic & Medicinal ChemistryBioorganic & Medicinal Chemistry Letters评为优秀审稿人。

指导了多位学生完成了科研项目研究和学科竞赛,获得了国家级大学生创新创业训练计划项目、省级大学生创新创业训练计划项目、湖南省大学生课外化学化工类创新作品竞赛、全国学生制药工程研究征文比赛“芙蓉学子”学术创新奖等。

研究方向1. 活性天然产物的结构修饰与创新药物研究;2. 小分子药物设计与合成工艺研究。

部分科研项目如下:

1)主持,基于贵州省特色民族药与中药活性成分的化学创新药物研究,贵州省千人创新创业项目,2019.06-2022.05150万元。

2)主持,苗药酢浆草中α-葡萄糖苷酶抑制剂类降血糖有效成分的定向发现与作用机制研究,贵州省科技厅基础研究计划重点项目,2021.04-2025.0430万元。

3)主持,厚果崖豆藤中新型查尔酮类微管蛋白抑制剂的化学结构改造和生物活性研究,贵州省科技厅基础研究计划一般项目,2019.01-2021.1210万元。

4)主持,基于天然产物Millepachine的新型微管蛋白抑制剂的设计、合成及抗肿瘤活性研究,国家自然科学基金地区项目,2017.01-2020.1234万元。

近三年发表的部分代表性论文如下:

[1] Min He, Meiyan Fan, Wenjing Liu, Yongjun Li, Guangcheng Wang*(通讯作者). Design, synthesis, molecular modeling, and biological evaluation of novel kojic acid derivatives containing bioactive heterocycle moiety as inhibitors of tyrosinase and antibrowning agents. Food Chemistry, 2021: 130241.(影响因子6.306JCR 1区)

[2] Min He, Meiyan Fan, Zhiyun Peng*, Guangcheng Wang*(通讯作者). An overview of hydroxypyranone and hydroxypyridinone as privileged scaffolds for novel drug discovery. European Journal of Medicinal Chemistry, 2021: 113546.(影响因子5.572JCR 1区)

[3] Zhiyun Peng1, Guangcheng Wang1(共同一作), Qiao-Hui Zeng, Yufeng Li, Haiquan Liu, Jing Jing Wang*, Yong Zhao*. A systematic review of synthetic tyrosinase inhibitors and their structure-activity relationship. Critical Reviews in Food Science and Nutrition, 2021: DOI: 10.1080/10408398.10402021.11871724. (影响因子7.862JCR 1区)

[4] Zhiyun Peng1, Guangcheng Wang1(共同一作), Qiao-Hui Zeng, Yufeng Li, Yi Wu, Haiquan Liu, Jing Jing Wang, Yong Zhao. Synthesis, antioxidant and anti-tyrosinase activity of 1,2,4-triazole hydrazones as antibrowning agents. Food Chemistry, 2021, 341: 128265.(影响因子6.306JCR 1区)

[5] Guangcheng Wang*(通讯作者), Meiyan Fan, Wenjing Liu, Min He, Yongjun Li, Zhiyun Peng*. Synthesis, biological evaluation and molecular docking investigation of new sulfonamide derivatives bearing naphthalene moiety as potent tubulin polymerization inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021,(影响因子4.673JCR 1区)

[6] Guangcheng Wang*(通讯作者), Wenjing Liu, Juan Tang, Xue Ma, Zipeng Gong, Yong Huang, Yongjun Li, Zhiyun Peng*. Design, synthesis, and anticancer evaluation of benzophenone derivatives bearing naphthalene moiety as novel tubulin polymerization inhibitors. Bioorganic Chemistry, 2020, 104: 104265. (影响因子4.831JCR 1区)

[7] Guangcheng Wang*(通讯作者), Wenjing Liu, Zhiyun Peng, Yong Huang, Zipeng Gong, Yongjun Li*. Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization. Bioorganic Chemistry, 2020, 103: 104141. (影响因子4.831JCR 1区)

[8] Guangcheng Wang*(通讯作者), Wenjing Liu, Zipeng Gong, Yong Huang, Yongjun Li*, Zhiyun Peng*. Design, synthesis, biological evaluation and molecular docking studies of new chalcone derivatives containing diaryl ether moiety as potential anticancer agents and tubulin polymerization inhibitors. Bioorganic Chemistry, 2020, 95: 103565. (影响因子4.831JCR 1区)

[9] Guangcheng Wang*(通讯作者), Wenjing Liu, Zipeng Gong, Yong Huang, Yongjun Li, Zhiyun Peng*. Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site. Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1): 139-144. (影响因子4.673JCR 1区)

[10] Guangcheng Wang*(通讯作者), Jie Qiu, Xiangwei Xiao, Anbai Cao, Fengjiao Zhou. Synthesis, biological evaluation and molecular docking studies of a new series of chalcones containing naphthalene moiety as anticancer agents. Bioorganic Chemistry, 2018, 76: 249-257.(影响因子4.831JCR 1区)

[11] Guangcheng Wang*(通讯作者), Zhiyun Peng, Jiebing Zhang, Jie Qiu, Zhenzhen Xie, Zipeng Gong*. Synthesis, biological evaluation and molecular docking studies of aminochalcone derivatives as potential anticancer agents by targeting tubulin colchicine binding site. Bioorganic Chemistry, 2018, 78: 332-340. (影响因子4.831JCR 1区)

[12] Guangcheng Wang(第一作者), Zhiyun Peng, Zipeng Gong, Yongjun Li*. Synthesis, biological evaluation, and docking studies of novel 5,6-diaryl-1,2,4-triazine thiazole derivatives as a new class of α-glucosidase inhibitors. Bioorganic Chemistry, 2018, 78: 195-200. (影响因子4.831JCR 1区)

联系方式E-mail: wanggch123@163.com

 

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